①Objective: To explore the pathway through which histone modification affects the risk of schizophrenia through the neurotransmitter system; ②Method: To use the WGCNA tool to establish the gene co-expression network between histone and neurotransmitter in the brain expression profiles of patients with schizophrenia, to analyze whether there are differences in histone-neurotransmitter associations between patients and healthy controls. ③The correlation of histone-neurotransmitter system in the patient"s brain was significantly reduced; by identifying the distribution of core histone-modifying genes with differential expression and newly mutated core histones in the network, we found CALM2, PRKAR1A, CAPZA2, BSN, GRIN1, LRFN3 Six candidate genes may be key genes for genetic risk of schizophrenia.