Intelligence era has put forward new and higher requirements for the cultivation of high-level innovative talents. As the main body of cultivating them, universities actively explore new teaching modes and plan to cultivate top-notch innovative talents, which is a forward-looking measure to respond to the technological revolution and industrial transformation. Biomedical textile materials are an emerging branch of textile science and engineering, belonging to interdisciplinary fields including textiles, materials, biology, and medicine. The knowledge background of students of students majoring in biomedical textile materials is mainly focused on textiles, integrating knowledge from related disciplines such as materials, biology, and medicine. Therefore, in order to improve the quality of cultivating top-notch innovative talents, we proposes a "point-line-range-system-bridge" teaching mode, which includes knowledge points, knowledge lines, knowledge ranges, knowledge systems, and knowledge bridges that integrate knowledge systems with other fields. Practice has proven that this mode can help students actively connect knowledge points into knowledge lines, then connect different course contents to expand their knowledge ranges, and finally form a relatively complete knowledge system of biomedical textile materials. More importantly, students are able to bridge and expand their established knowledge system with the latest technological advancements, social and family resources, and personalized knowledge and experience, continuously forming a scalable and personalized new knowledge system. Innovative and creative abilities of students, as well as their ability to solve complex engineering problems have been significantly improved. This provides a solid foundation for their continuous and lifelong learning.