Objective To explore the value of the integrating curriculum ideology and politics with “CBL+PBL+TBL” multimodal teaching in medical imaging majors. Methods The 2021 undergraduate program in medical imaging technology, jointly operated by Shanghai Health Medical College and Shanghai Ninth People’s Hospital of Shanghai Jiaotong University School of Medicine, was taken as the research object. The teaching of digestive system disease imaging diagnosis was piloted with 12 class hours. And the curriculum ideology and politics combined with the “CBL+PBL+TBL” multimodal teaching method was adopted. The teaching effectiveness was evaluated through performance assessments, questionnaire surveys, and satisfaction surveys. Results The daily score was (99.39±2.423) points, the theoretical assessment score was (94.39±2.120) points, the self-rating scale of self-directed learning assessment scale score was (253.50±34.898) points, the teaching mode evaluation was (45.20±9.657) points, and the satisfaction rate was 96%. Conclusion The method of integrating curriculum ideology and politics with “CBL+PBL+TBL” multimodal teaching can effectively mobilize students’ self-learning ability and teamwork ability, and the teaching effect has been recognized and affirmed by a large number of students.