Medical-engineering integration plays a significant role in promoting the development of original medical technologies and high-end medical equipment in China. To address the challenges in medical-engineering integration in previous teaching practices, this paper focuses on building an excellent teaching team, with the medicalengineering integration as the core. It emphasizes high-quality cultivation of innovative talent, and through toplevel design and breaking down knowledge silos with a curriculum matrix, creates an innovative education platform. By strengthening medical-engineering integration, and optimizing teaching resources to enhance capabilities, it fosters a cohesive educational force. And it promotes the transformation of “knowledge into innovation” to achieve deep integration of small-scale course exercises with innovation projects. Ultimately, this paper establishes a more comprehensive talent cultivation system, significantly improving students’ innovative abilities and effectively supporting the training of innovative professionals in biomedical engineering.