Objective To investigate the effects of Transcervi Calresection of Endometrial Polyps(TCRP) combined with intranegative uterine pressure aspiration on the sexual life quality and pregnancy outcome of multiple endometrial polyps (EP) patients complicated with infertility. Methods According to the surgical method, 127 patients with multiple EP complicated with infertility in Longhu Hospital, Xuchang from January 18, 2021 to January 18, 2024 were divided into two groups. The control group (63 cases) received TCRP treatment, while the observation group (64 cases) received negative intrauterine pressure suction surgery on the basis of TCRP treatment. Compare the surgical indicators, sexual quality of life, and pregnancy outcomes between two groups. Results The operation time of observation group was shorter than that of control group, the incidence of perioperative complications was lower, and the amount of intraoperative bleeding was higher (P ＜ 0.05). Compared with the control group, the BISF-W score was higher in the observation group (P ＜ 0.05). After 12 months follow-up, the pregnancy success rate in observation group (31.25%) was higher than that in control group (14.29%) (P ＜ 0.05). Conclusion TCRP combined with negative uterine pressure aspiration can shorten the operative time and reduce perioperative complications in the treatment of multiple EP patients with infertility, thereby improving the quality of sexual life and increasing the success rate of pregnancy.