Objective To investigate the impact of a predictive nursing intervention program on physical function rehabilitation of emergency stroke patients. Methods A prospective controlled study design was adopted, selecting 88 stroke patients who visited the emergency department of Zhongshan Hospital Affiliated to Xiamen University from April 2022 to March 2024. Based on the time of visit, they were divided into a control group (42 cases) and an observation group (46 cases). The control group received routine care, while the observation group received a predictive nursing intervention program in addition to routine care. Physical function (Barthel Index, Fugl-Meyer Scale, mRS score), motor function (6-minute walk test, standing balance test), psychological status (PHQ-9 depression score, GAD-7 anxiety score), and nursing satisfaction were compared between the two groups before and after intervention. Results After the intervention, both groups showed significant improvements in physical function, motor function, and psychological status (P＜0.05). The observation group had greater improvements in the Barthel Index, Fugl-Meyer Scale, mRS score, 6-minute walk test, standing balance test, PHQ-9 depression score, and GAD-7 anxiety score compared to the control group (P ＜ 0.05). Nursing satisfaction in the observation group was significantly higher than that in the control group (P ＜ 0.05). Conclusions The predictive nursing intervention program can effectively improve the physical function, motor ability, and psychological status of emergency stroke patients, and increase nursing satisfaction. It is worthy of promotion and application in clinical practice.